3-D images are essential for the study of tissue networks to characterize their morphologies in space. We establish tissue labeling and microscopic tools for high-definition 3-D imaging of mouse and human tissues.
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Team and collaborators
PI: Dr. Shiue-Cheng (Tony) Tang; Dr. Pankaj J. Pasricha; Dr. Ann-Shyn Chiang; Dr. Yuan-Chiang Chung; Dr. Michael German; Dr. Chester Chamberlain; Dr. Luc Baeyens; David Scheel; Dr. Shien-Tung Pan; Dr. Ming-Yin Shen; Dr. Yung-Chi Hou, Dr. Tsung-Lin Yang; Dr. Jyuhn-Huarng Juang; Dr. Chia-Ning Shen; Dr. Tzu-En Hua; Dr. Ya-Yuan Fu; Dr. Yuan-An Liu; Ph.D. candidate Pei-Yu Lin; M.Sc. Shih-Jung Peng; M.Sc. Yu-Chen Chiu; M.Sc. Chia-Tung Hsu; Hung-Jen Chien
Our laboratory develops optical and histological methods to acquire 3-D images of tissue microstructure, vasculature, and innervation. We prepare transparent specimens with optical clearing to reveal the fluorescently labeled tissue architectures in space. We specialize in digestive and metabolic tissues, such as the intestine and pancreas, in health and disease, and we perform qualitative and quantitative analyses of the 3-D image data of these tissues.
Our research topics include: 3-D imaging, illustration, and quantitation of interstitial cell of Cajal (ICC) in human colon, whole-villus neurohistology with optical clearing, imaging of the islet neural network, and characterization of islet neurovascular remodeling in obesity and diabetes.
At the Movies: 3-D Technology & Gastrointestinal Histology